Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 81, Issue -, Pages 252-260Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.08.020
Keywords
Black TiO2; Nanomaterial; Near infrared light; Bladder cancer; Phototherapy
Categories
Funding
- National Natural Science Foundation of China [21376065, 51672073, 81573134]
- Natural Science Foundation of Heilongjiang Province [LC2017038]
- China Postdoctoral Science Foundation [2017M611399]
- Heilongjiang Postdoctoral Startup Fund [LBH-Q14135]
- University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [UNPYSCT-2015014, UNPYSCT-2016018]
- Postdoctoral Science Foundation of Heilongjiang Province [LBH-Z16150]
- Harbin Medical University [2016JCZX13]
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The black TiO2 nanoparticles are synthesized via a facile calcination method combined with an in-situ controllable solid-state reaction approach. The results indicate that the photocatalyst with a narrow band gap of similar to 2.32 eV extends the photoresponse to visible light and near infrared region. And thus more reactive oxygen species can be obtained to induce the cell-killing under 808 nm light triggering. The as-obtained black TiO2 nanoparticles exhibiting low toxicity, good biocompatibility and high anticancer effect in vitro, is demonstrated as efficient photosensitizers for phototherapy to kill the bladder cancer cells. These findings suggest that the facile synthetic black TiO2 nanomaterials will have broad application in biomedicine.
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