Journal
HEPATOLOGY COMMUNICATIONS
Volume 3, Issue 4, Pages 456-470Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/hep4.1331
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Funding
- Japan Society for the Promotion of Science [16H04699, 16H05290]
- Japan Agency for Medical Research and Development (AMED) [17929503, 18fk0210004h0003]
- Grants-in-Aid for Scientific Research [16H04699, 16H05290] Funding Source: KAKEN
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The gut and the liver are anatomically and physiologically connected, and this gut-liver axis exerts various influences on liver pathology. The gut microbiota consists of various microorganisms that normally coexist in the human gut and have a role of maintaining the homeostasis of the host. However, once homeostasis is disturbed, metabolites and components derived from the gut microbiota translocate to the liver and induce pathologic effects in the liver. In this review, we introduce and discuss the mechanisms of liver inflammation, fibrosis, and cancer that are influenced by gut microbial components and metabolites; we include recent advances in molecular-based therapeutics and novel mechanistic findings associated with the gut-liver axis and gut microbiota.
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