Journal
MATERIALS TODAY-PROCEEDINGS
Volume 9, Issue -, Pages 661-668Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matpr.2018.10.390
Keywords
Dihydropyrimidinones; phosphorofluoridic acid; efficient and simple protocol; solvent free reaction
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Funding
- Nano Mission, DST, Government of India [SR/NM/NS-20/2014]
- Centre for Nano and material Sciences (CNMS) Jain University, Bangalore through the basic research grant of Jain University [11(39)/17/005/2017SG]
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An efficient and simple protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from aldehydes, ethyl acetoacetate and urea using phosphorofluridic acid as the catalyst under solvent free conditions. In comparison with the classical Biginelli reaction, with the given conditions and catalysts, 10 mol% of phosphorofluroridic acid showed excellent catalytic activity. This method has the advantage of being eco-friendly, has an easy work up process and produces high yields in short reaction time. (C) 2018 Elsevier Ltd. All rights reserved.
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