Journal
MATERIALS LETTERS
Volume 207, Issue -, Pages 157-160Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2017.07.023
Keywords
Smart materials; Methylcellulose; Rheology; UV spectroscopy; Cell sheet engineering
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Methylcellulose (MC) hydrogels change their affinity to water depending on their temperature and can thus be used as substrates for cell sheet engineering. In this work, we characterize the thermo-responsive properties of 8% w/v MC hydrogels, produced in two saline solutions (i.e., Na2SO4 and phosphate buffered saline) at different concentrations, by investigating the rheological properties and the UV-absorbance in function of temperature. Both rheological and UV-spectroscopy tests showed that the addition of salts to MC hydrogels allowed lowering the LCST of the MC hydrogel; moreover, hydrogels produced in 0.1 M Na2SO4 or PBS 20 g/L were proved to be particularly promising for cell sheet engineering application, showing a LCST below 37 degrees C. (C) 2017 Elsevier B.V. All rights reserved.
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