Journal
TRANSCRIPTION-AUSTIN
Volume 10, Issue 2, Pages 57-75Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21541264.2018.1523668
Keywords
Enhancer; CDK9; P-TEFb; 7SK; RNA polymerase II; Transcription; Pausing; Elongation; Cancer; HIV; Disease
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Funding
- National Institute of Allergy and Infectious Diseases [R01AI114362, R33AI116222]
- National Science Foundation [2016220513]
- Welch Foundation [I-1872]
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Cyclin-dependent kinase 9 (CDK9) is critical for RNA Polymerase II (Pol II) transcription initiation, elongation, and termination in several key biological processes including development, differentiation, and cell fate responses. A broad range of diseases are characterized by CDK9 malfunction, illustrating its importance in maintaining transcriptional homeostasis in basal- and signal-regulated conditions. Here we provide a historical recount of CDK9 discovery and the current models suggesting CDK9 is a central hub necessary for proper execution of different steps in the transcription cycle. Finally, we discuss the current therapeutic strategies to treat CDK9 malfunction in several disease states.
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