Journal
HELIYON
Volume 5, Issue 3, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2019.e01426
Keywords
Cell biology; Molecular biology; Pharmaceutical science
Categories
Ask authors/readers for more resources
Studies have shown that diesel exhaust particles (DEP) induced oxidative stress and inflammation. This present study examined the molecular effects of aqueous rooibos extract (RE) on the cardiovascular toxic effect of methanol extract of DEP in exposed Wistar rats. The results showed that DEP caused significant (p < 0.001) increase in MDA and CDs levels in the aorta and heart but this increase was significantly (p < 0.001) attenuated by rooibos extract. DEP induced IL-8, TNF alpha, IL-1 beta and decreased IL-10 gene expressions, all of which were reversed in the presence of rooibos extract. The expression of NF-kappa B, and I kappa KB genes were also significantly (p < 0.001) induced by DEP in both tissues, but pre-treatment with RE attenuated these effects. In contrast, DEP repressed I kappa B mRNA level, which was significantly (p < 0.001) reversed by rooibos extract pre-treatment. In addition, pre-treatment with rooibos extract attenuated the increased Nrf2 and HO-1 mRNA levels caused by DEP. This indicates the potential of rooibos extract to protect against DEP-induced cardiovascular toxicity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available