Journal
ACS OMEGA
Volume 4, Issue 3, Pages 5496-5508Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.8b03676
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Funding
- European Commission (PANA project) [686009]
- Xunta de Galicia [GPC2017/015]
- Conselleria de Educacion Program for the Development of Strategic Grouping in Materials
- University of Santiago de Compostela [ED431E2018/08]
- Program for the Consolidation of Research Units of Competitive Reference GRC2017 [ED431C 2017/22]
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The development of scaffolds with suitable physicochemical and mechanical properties allowing for the structural regeneration of injured bone and recovery of the natural biological functionality is still a challenge in the tissue engineering field. Nanostructured materials with added theranostic abilities, together with an interconnected hierarchy of pores, offer the possibility to provide a new generation of bone implants. In this work, scaffolds with highly porous and resistant three-dimensional structures have been successfully developed by homogeneously embedding mesoporous silica nanostructures in a bioactive matrix of chitosan/kappa-carrageenan. Moreover, magnetite (Fe3O4) nanoparticles were also added to the mesoporous scaffold to include additional magnetic functionalities for diagnostic or therapeutic actions. The complete physicochemical characterization shows mesoporous materials with a wide range of interconnected pores, remarkable surface roughness, and large effective surface area, suitable for cell adhesion. In accordance to these properties, a simvastatin loading and release assay showed high loading capacities and sustained release over a long period of time. Together with a suitable resistance against degradation and biocompatible performance assessed by cell viability assays, these scaffolds show interesting features for delivering drugs with activity in bone regeneration processes.
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