Biomimetic folding of small organic molecules driven by multiple non- covalent interactions

Here we report our research on biomimetic folding architectures self-assembled hierarchically from well-designed UPy-based monomers with low molecular weight (MW < 400 Da). These monomers are first dimerized via quadruple hydrogen bonding and then form folded dimers with the assistance of - interactions. More interestingly, the folded dimer further formed one-dimensional supramolecular stacks through additional weak - interactions in the solid state. Similar to DNA, these well-defined structures are stabilized by the concerted hydrogen bonding and - interaction in a synergistic manner, which would provide inspiration for constructing biomimetic self-folding materials.