Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 27, Pages 3907-3910Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01262a
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Funding
- Host Institutes, C. B. Patel Research Centre
- Bhabha Atomic Research Centre
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A fluorescence turn-on probe for amyloid detection in the extreme near-infrared region (>750 nm) is a highly desirable technological evolution from the view point of potential in vivo applications. Herein, we report a molecular rotor-based amyloid sensor probe which, on binding to the insulin amyloid fibril, registers a large turn-on emission in the near-infrared region, and records an exceptionally large red-shifted emission wavelength of approximate to 770 nm along with a Stokes' shift of approximate to 150 nm, the highest reported to date for any amyloid sensor probe, in the insulin fibril bound form, in the near-infrared region. Importantly, when bound to insulin fibrils, this probe also exhibits an exceptionally large red-shift of approximate to 120 nm in the absorption spectra, which enables the naked eye in vitro detection of amyloid fibrils.
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