Journal
TOXICS
Volume 7, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/toxics7010017
Keywords
epitranscriptomics; tRNA modifications; stress response mechanisms; codon-biased translation
Categories
Funding
- National Institutes of Health [R01ES026856, R01ES024615]
- National Science Foundation of Singapore
- Early Postdoc. Mobility Fellowship from the Swiss National Science Foundation [P2SKP_174681]
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Living organisms respond to environmental changes and xenobiotic exposures by regulating gene expression. While heat shock, unfolded protein, and DNA damage stress responses are well-studied at the levels of the transcriptome and proteome, tRNA-mediated mechanisms are only recently emerging as important modulators of cellular stress responses. Regulation of the stress response by tRNA shows a high functional diversity, ranging from the control of tRNA maturation and translation initiation, to translational enhancement through modification-mediated codon-biased translation of mRNAs encoding stress response proteins, and translational repression by stress-induced tRNA fragments. tRNAs need to be heavily modified post-transcriptionally for full activity, and it is becoming increasingly clear that many aspects of tRNA metabolism and function are regulated through the dynamic introduction and removal of modifications. This review will discuss the many ways that nucleoside modifications confer high functional diversity to tRNAs, with a focus on tRNA modification-mediated regulation of the eukaryotic response to environmental stress and toxicant exposures. Additionally, the potential applications of tRNA modification biology in the development of early biomarkers of pathology will be highlighted.
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