Journal
MARINE ENVIRONMENTAL RESEARCH
Volume 128, Issue -, Pages 58-69Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.marenvres.2016.05.002
Keywords
Drug discovery; Microalgae; Bacteria; Blue growth; Marine natural products; Cultivation methods; Molecular biology approaches
Funding
- PhD (PhD in Biology, University of Naples Federico II) fellowship - Stazione Zoologica Anton Dohrn
- Stazione Zoologica Anton Dohrn internal funding
- PharmaSea project - EU Seventh Framework Programme [312184]
- Bio-Organic Chemistry Unit of the Institute of Biomolecular Chemistry-CNR, Pozzuoli, Naples
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There is an urgent need to discover new drug entities due to the increased incidence of severe diseases as cancer and neurodegenerative pathologies, and reducing efficacy of existing antibiotics. Recently, there is a renewed interest in exploring the marine habitat for new pharmaceuticals also thanks to the advancement in cultivation technologies and in molecular biology techniques. Microorganisms represent a still poorly explored resource for drug discovery. The possibility of obtaining a continuous source of bioactives from marine microorganisms, more amenable to culturing compared to macro-organisms, may be able to meet the challenging demands of pharmaceutical industries. This would enable a more environmentally-friendly approach to drug discovery and overcome the over-utilization of marine resources and the use of destructive collection practices. The importance of the topic is underlined by the number of EU projects funded aimed at improving the exploitation of marine organisms for drug discovery. (C) 2016 Elsevier Ltd. All rights reserved.
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