Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 26, Pages 3705-3708Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc10212k
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Funding
- National Natural Science Foundation of China [21425208, 21672238, 81760624, 21702241]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- Young Elite Scientists Sponsorship Program by Cast of the China Association for Science and Technology [2015-41]
- Guizhou Province [2017-1225, 2018-1427]
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A palladium-catalyzed cross-coupling of unactivated alkylzinc reagents with 2-bromo-3,3,3-trifluoropropene (BTP) has been developed, which was used as a key step to prepare a series of trifluoromethylated and difluoromethylated amino acids that are of great interest in peptide/protein based chemical biology. The advantages of the synthesis of these fluorinated amino acids are synthetic simplicity and diversity from a simple and readily available key intermediate alpha-trifluoromethylalkene-containing amino acid, providing a facile route for applications in medicinal chemistry and life science.
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