Journal
MARINE DRUGS
Volume 15, Issue 11, Pages -Publisher
MDPI AG
DOI: 10.3390/md15110339
Keywords
Dichotomomyces cejpii; diverse secondary metabolites; amino acid-directed strategy; nitrogen-containing compounds; bioactivity
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Funding
- Guangdong Provincial Science and Technology Research Program [2014A020217004, 2015A020216007, 2016A020222004]
- Guangzhou Science and Technology Research Program [2014J4100059]
- Fundamental Research Funds for the Central Universities [15ykpy05, 14yksh01]
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By adding l-tryptophan and l-phenylalanine to GPY medium, twenty-eight compounds, including amides, polyketides, a sesquiterpenoid, a diterpenoid, a meroterpenoid, diketopiperazines, -carbolines, fumiquinazolines, and indole alkaloids, were discovered from the marine-derived fungus Dichotomomyces cejpii F31-1, demonstrating the tremendous biosynthetic potential of this fungal strain. Among these compounds, four amides dichotomocejs A-D (1-4), one polyketide dichocetide A (5), and two diketopiperazines dichocerazines A-B (15 and 16) are new. The structures of these new compounds were determined by interpreting detailed spectroscopic data as well as calculating optical rotation values and ECD spectra. Obviously, Dichotomomyces cejpii can effectively use an amino acid-directed strategy to enhance the production of nitrogen-containing compounds. Dichotomocej A (1) displayed moderate cytotoxicity against the human rhabdomyosarcoma cell line RD with an IC50 value of 39.1 mu M, and pityriacitrin (22) showed moderate cytotoxicity against the human colon carcinoma cell line HCT116 with an IC50 value of 35.1 mu M.
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