4.7 Review

Multifaceted Applications of Chitosan in Cancer Drug Delivery and Therapy

Journal

MARINE DRUGS
Volume 15, Issue 4, Pages -

Publisher

MDPI AG
DOI: 10.3390/md15040096

Keywords

chitosan; gene delivery; drug delivery; adjuvant; cancer; nanoparticle

Funding

  1. National Institutes of Health (NIH) [R01 CA167516]
  2. Stephenson Cancer Center Seed Grant
  3. Presbyterian Health Foundation Seed Grant
  4. Presbyterian Health Foundation Bridge Grant
  5. Jim and Christy Everest Endowed Chair in Cancer Developmental Therapeutics, at the University of Oklahoma Health Sciences Center

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Chitosan is a versatile polysaccharide of biological origin. Due to the biocompatible and biodegradable nature of chitosan, it is intensively utilized in biomedical applications in scaffold engineering as an absorption enhancer, and for bioactive and controlled drug release. In cancer therapy, chitosan has multifaceted applications, such as assisting in gene delivery and chemotherapeutic delivery, and as an immunoadjuvant for vaccines. The present review highlights the recent applications of chitosan and chitosan derivatives in cancer therapy.

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