Journal
MARINE DRUGS
Volume 15, Issue 1, Pages -Publisher
MDPI AG
DOI: 10.3390/md15010023
Keywords
soft coral; Klyxum flaccidum; cembranoid; NO inhibition; cytotoxicity
Categories
Funding
- Ministry of Science and Technology [MOST 102-2628-B-110-002-MY2, 104-2320-B-110-001-MY2]
- Aim for the Top University Program from the Ministry of Education of Taiwan [05C030205]
- National Sun Yat-sen University-Kaohsiung Medical University (NSYSU-KMU) Joint Research Project of Taiwan [NSYSUKMU 105-I008]
- Taiwan Protein Project [MOST 105-0210-01-12-01]
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New cembranoids klyflaccicembranols A-I (1-9), along with gibberosene D (10), have been isolated from the organic extract of a Formosan soft coral Klyxum flaccidum. Their structures were established by extensive spectroscopic analyses, including 2D NMR spectroscopy, and spectral data comparison with related structures. The cytotoxicity of the isolated metabolites, as well as their nitric oxide (NO) inhibitory activity, were evaluated and reported. Metabolites 2, 4, 6, 8 and 9 were found to exhibit variable activities against a limited panel of cancer cell lines in a range of IC50 16.5-49.4 mu M. Among the tested cembranoids, compounds 4, 5, 6, and 9 significantly inhibited NO production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages at a dose of 50 mu g/mL.
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