Journal
MARINE DRUGS
Volume 15, Issue 12, Pages -Publisher
MDPI AG
DOI: 10.3390/md15120373
Keywords
shrimp disease; AHPND; Photorhabdus insect-related toxin; PirA(vp); PirB(vp)
Categories
Funding
- Ministry of Science and Technology [MOST 106-2311-B-038-002]
Ask authors/readers for more resources
In aquaculture, shrimp farming is a popular field. The benefits of shrimp farming include a relatively short grow-out time, high sale price, and good cost recovery. However, outbreaks of serious diseases inflict serious losses, and acute hepatopancreatic necrosis disease (AHPND) is an emerging challenge to this industry. In South American white shrimp (Penaeus vannamei) and grass shrimp (Penaeus monodon), this disease has a 70-100% mortality. The pathogenic agent of AHPND is a specific strain of Vibrio parahaemolyticus which contains PirA(vp) and PirB(vp) toxins encoded in the pVA1 plasmid. PirA(vp) and PirB(vp) have been shown to cause the typical histological symptoms of AHPND in infected shrimps, and in this review, we will focus on our structural understanding of these toxins. By analyzing their structures, a possible cytotoxic mechanism, as well as strategies for anti-AHPND drug design, is proposed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available