Journal
PHARMACOLOGY
Volume 103, Issue 5-6, Pages 257-262Publisher
KARGER
DOI: 10.1159/000496422
Keywords
KCNQ/M channels; Osteoarthritic pain; Dorsal root ganglia; Modulators
Categories
Funding
- National Natural Science Foundation of China [31401199, 31872788, 81501911]
- foundation of education department of Hebei Province [QN2018007]
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Osteoarthritic pain has a strong impact on patients' quality of life. Understanding the pathogenic mechanisms underlying osteoarthritic pain will likely lead to the development of more effective treatments. In the present study of osteoarthritic model rats, we observed a reduction of M-current density and a remarkable decrease in the levels of KCNQ2 and KCNQ3 proteins and mRNAs in dorsal root ganglia (DRG) neurons, which were associated with hyperalgesic behaviors. The activation of KCNQ/M channels with flupirtine significantly increased the mechanical threshold and prolonged the withdrawal latency of osteoarthritic model rats at 3-14 days after model induction, and all effects of flupirtine were blocked by KCNQ/M-channel antagonist, XE-991. Together, these results indicate that suppression of KCNQ/M channels in primary DRG neurons plays a crucial role in the development of osteoarthritic pain. (c) 2019 S. Karger AG, Basel
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