4.7 Article

New Cytotoxic Terpenoids from Soft Corals Nephthea chabroli and Paralemnalia thyrsoides

Journal

MARINE DRUGS
Volume 15, Issue 12, Pages -

Publisher

MDPI AG
DOI: 10.3390/md15120392

Keywords

Nephthea chabroli; Paralemnalia thyrsoides; cytotoxicity

Funding

  1. Ministry of Science and Technology [MOST105-2320-B-110-003-MY3]
  2. NSYSUNKMU [106-P010]
  3. NSYSUKMU [106-P016]

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A novel cytotoxic diterpenoid, chabrolin A (1) (possessing an unprecedented terpenoid skeleton), as well as three new cytotoxic sesquiterpenoids, parathyrsoidins E-G (2-4), were isolated by cytotoxicity-guided fractionation from soft corals Nephtheachabroli and Paralemnalia thyrsoides. The structures of the new compounds were determined by extensive analysis of spectroscopic data.

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