Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 7, Issue 14, Pages 2320-2329Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb00301k
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Funding
- Key Program of National Natural Science Foundation of China [21838010, 21676270, 21890762]
- National Natural Science Foundation of China-Key Projects of Shanxi Coal Based Low Carbon Joint Foundation [U1610222]
- International Science Cooperation Program of Chinese Academy of Sciences [211211KYSB]
- National Key Research and Development Plan [2016YFF0203700]
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In this study, in situ sulfur-doped carbon nitride nanosheets (S-g-C3N4 NSs) are used as the signal readout for the sensitive and selective sensing of l-cysteine (l-Cys) in human serum samples based on the competitive coordination chemistry of Cu2+ between l-Cys and S-g-C3N4 NSs. S-g-C3N4 NSs are prepared by using trithiocyanuric acid as a precursor for the first time, which exhibits stronger electrogenerated chemiluminescence (ECL) intensity compared with pristine graphitic carbon nitride nanosheets (g-C3N4 NSs). The ECL signals of the S-g-C3N4 NSs can be quenched by Cu2+ and the subsequent presence of l-Cys can recover the ECL signals of the S-g-C3N4 NSs. These changes are ascribed to the higher coordination ability between Cu2+ and l-Cys than that between Cu2+ and the S-g-C3N4 NSs. On the basis of this, the concentration of l-Cys can be quantitatively determined. Under optimized conditions, the ECL intensity recovery shows a linear relationship with the l-Cys concentration range from 30 nM to 0.2 mM with a lower detection limit of 5 nM (S/N = 3). The proposed method is highly sensitive and selective and is thus particularly useful for fast and simple clinical diagnosis of diseases, such as Alzheimer's disease and cardiovascular disease.
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