Journal
BIOMOLECULES
Volume 9, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/biom9030106
Keywords
oral mucosal lesions; medicinal plants; plant extracts; phytochemicals; curcumin; lycopene; Matricaria chamomilla; Aloe vera
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Funding
- Portuguese Foundation for Science and Technology (FCT-Portugal) [UID/BIM/04293/2013]
- NORTE2020-Programa Operacional Regional do Norte [NORTE-01-0145-FEDER-000012]
- Biotechnology and Energy-LEPABE - national funds through FCT/MCTES (PIDDAC)
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Oral mucosal lesions have many etiologies, including viral or bacterial infections, local trauma or irritation, systemic disorders, and even excessive alcohol and tobacco consumption. Folk knowledge on medicinal plants and phytochemicals in the treatment of oral mucosal lesions has gained special attention among the scientific community. Thus, this review aims to provide a brief overview on the traditional knowledge of plants in the treatment of oral mucosal lesions. This review was carried out consulting reports between 2008 and 2018 of PubMed (Medline), Web of Science, Embase, Scopus, Cochrane Database, Science Direct, and Google Scholar. The chosen keywords were plant, phytochemical, oral mucosa, leukoplakia, oral lichen planus and oral health. A special emphasis was given to certain plants (e.g., chamomile, Aloe vera, green tea, and coffea) and plant-derived bioactives (e.g., curcumin, lycopene) with anti-oral mucosal lesion activity. Finally, preclinical (in vitro and in vivo) and clinical studies examining both the safety and efficacy of medicinal plants and their derived phytochemicals were also carefully addressed.
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