Journal
RSC ADVANCES
Volume 9, Issue 16, Pages 8707-8713Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra00020h
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Funding
- National Natural Science Foundation of China [81100558]
- Integrated Technology Application Research in Public Welfare of Anhui Province [1704f0804012]
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Depression is the leading cause of disability worldwide, and its treatment represents a major clinical challenge. The hypothalamus-pituitary-adrenal (HPA) axis has been known to play a crucial role in depression and serves as a target for antidepressants. Acid-sensing ion channels (ASICs) are widely expressed in the nervous system and may be implicated in depression. Whether ASICs could act on the HPA axis to affect depression-related behaviors is not fully understood. In this study, we investigated the effect of inhibition of ASICs on the HPA axis activity in chronic stress-subjected rats. We found that treatment with the ASIC selective antagonist amiloride reversed chronic stress-induced elevation of adrenocorticotropic hormone (ACTH) and corticosterone in serum, which is reflective of the HPA axis activity. In addition, amiloride also alleviated chronic stress-induced anhedonia-like behavior. These results suggest that inhibition of ASICs may act on the HPA axis to alleviate the symptoms of depression.
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