Related references
Note: Only part of the references are listed.In vivo high-throughput profiling of CRISPR-Cpf1 activity
Hui K. Kim et al.
NATURE METHODS (2017)
Highly Efficient Cpf1-Mediated Gene Targeting in Mice Following High Concentration Pronuclear Injection
Dawn E. Watkins-Chow et al.
G3-GENES GENOMES GENETICS (2017)
Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems
Mari Yamada et al.
MOLECULAR CELL (2017)
Diversity and evolution of class 2 CRISPR-Cas systems
Sergey Shmakov et al.
NATURE REVIEWS MICROBIOLOGY (2017)
Nucleic acid detection with CRISPR-Cas13a/C2c2
Jonathan S. Gootenberg et al.
SCIENCE (2017)
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni
Eunji Kim et al.
NATURE COMMUNICATIONS (2017)
Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions
Supriya Sinha et al.
PLOS GENETICS (2017)
Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
Liang Liu et al.
CELL (2017)
Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation
Antonia A. Dominguez et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Rationally engineered Cas9 nucleases with improved specificity
Ian M. Slaymaker et al.
SCIENCE (2016)
Zygote-mediated generation of genome-modified mice using Streptococcus thermophilus 1-derived CRISPR/Cas system
Wataru Fujii et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells
Eszter Toth et al.
BIOLOGY DIRECT (2016)
Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes
Van Trung Chu et al.
BMC BIOTECHNOLOGY (2016)
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
Takashi Yamano et al.
CELL (2016)
Structure and Engineering of Francisella novicida Cas9
Hisato Hirano et al.
CELL (2016)
Naturally Occurring Off-Switches for CRISPR-Cas9
April Pawluk et al.
CELL (2016)
Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition
Pu Gao et al.
CELL RESEARCH (2016)
Utilization of the CRISPR/Cas9 system for the efficient production of mutant mice using crRNA/tracrRNA with Cas9 nickase and FokI-dCas9
Miho Terao et al.
EXPERIMENTAL ANIMALS (2016)
Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study
R. Kaminski et al.
GENE THERAPY (2016)
Highly multiplexed CRISPR-Cas9-nuclease and Cas9-nickase vectors for inactivation of hepatitis B virus
Tetsushi Sakuma et al.
GENES TO CELLS (2016)
DNA Sequence Alignment during Homologous Recombination
Eric C. Greene
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9
Carolin Anders et al.
MOLECULAR CELL (2016)
Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9
Seiichi Hirano et al.
MOLECULAR CELL (2016)
The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells
Ciaran M. Lee et al.
MOLECULAR THERAPY (2016)
Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome
Maximilian Mueller et al.
MOLECULAR THERAPY (2016)
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
Ines Fonfara et al.
NATURE (2016)
The crystal structure of Cpf1 in complex with CRISPR RNA
De Dong et al.
NATURE (2016)
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver et al.
NATURE (2016)
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
Alexandra East-Seletsky et al.
NATURE (2016)
Generation of knockout mice by Cpf1-mediated gene targeting
Yongsub Kim et al.
NATURE BIOTECHNOLOGY (2016)
Targeted mutagenesis in mice by electroporation of Cpf1 ribonucleoproteins
Junho K. Hur et al.
NATURE BIOTECHNOLOGY (2016)
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
Christopher D. Richardson et al.
NATURE BIOTECHNOLOGY (2016)
Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
Daesik Kim et al.
NATURE BIOTECHNOLOGY (2016)
Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci
Baohui Chen et al.
NUCLEIC ACIDS RESEARCH (2016)
Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia
Lin Ye et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
Fuguo Jiang et al.
SCIENCE (2016)
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
Omar O. Abudayyeh et al.
SCIENCE (2016)
Generation and validation of PAX7 reporter lines from human iPS cells using CRISPR/Cas9 technology
Jianbo Wu et al.
STEM CELL RESEARCH (2016)
Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair
Joffrey Mianne et al.
GENOME MEDICINE (2016)
Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing
Yuichiro Miyaoka et al.
SCIENTIFIC REPORTS (2016)
Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9
Xiya Zhang et al.
SCIENTIFIC REPORTS (2016)
Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase
Reto Eggenschwiler et al.
SCIENTIFIC REPORTS (2016)
CRISPR RNA-guided FokI nucleases repair a PAH variant in a phenylketonuria model
Yi Pan et al.
SCIENTIFIC REPORTS (2016)
Crystal Structure of Staphylococcus aureus Cas9
Hiroshi Nishimasu et al.
CELL (2015)
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
Bernd Zetsche et al.
CELL (2015)
Fanconi Anemia Gene Editing by the CRISPR/Cas9 System
Mark J. Osborn et al.
HUMAN GENE THERAPY (2015)
Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems
Sergey Shmakov et al.
MOLECULAR CELL (2015)
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
Benjamin P. Kleinstiver et al.
NATURE (2015)
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran et al.
NATURE (2015)
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
Benjamin P. Kleinstiver et al.
NATURE BIOTECHNOLOGY (2015)
A split-Cas9 architecture for inducible genome editing and transcription modulation
Bernd Zetsche et al.
NATURE BIOTECHNOLOGY (2015)
DNA-binding-domain fusions enhance the targeting range and precision of Cas9
Mehmet Fatih Bolukbasi et al.
NATURE METHODS (2015)
Off-target mutations are rare in Cas9-modified mice
Vivek Iyer et al.
NATURE METHODS (2015)
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
Daesik Kim et al.
NATURE METHODS (2015)
An updated evolutionary classification of CRISPR-Cas systems
Kira S. Makarova et al.
NATURE REVIEWS MICROBIOLOGY (2015)
Development of an intein-mediated split-Cas9 system for gene therapy
Dong-Jiunn Jeffery Truong et al.
NUCLEIC ACIDS RESEARCH (2015)
Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems
Pawel Bialk et al.
PLOS ONE (2015)
Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering
Mustapha Aouida et al.
PLOS ONE (2015)
Multicolor CRISPR labeling of chromosomal loci in human cells
Hanhui Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Rational design of a split-Cas9 enzyme complex
Addison V. Wright et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Targeted gene editing by transfection of in vitro reconstituted Streptococcus thermophilus Cas9 nuclease complex
Monika Glemzaite et al.
RNA BIOLOGY (2015)
A Cas9-guide RNA complex preorganized for target DNA recognition
Fuguo Jiang et al.
SCIENCE (2015)
Generation of mutant mice via the CRISPR/Cas9 system using FokI-dCas9
Satoshi Hara et al.
SCIENTIFIC REPORTS (2015)
Efficient genome engineering in eukaryotes using Cas9 from Streptococcus thermophilus
Kun Xu et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2015)
Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications
Ari E. Friedland et al.
GENOME BIOLOGY (2015)
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
Hiroshi Nishimasu et al.
CELL (2014)
Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes
Shuo-Ting Yen et al.
DEVELOPMENTAL BIOLOGY (2014)
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
Sojung Kim et al.
GENOME RESEARCH (2014)
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Hind Ghezraoui et al.
MOLECULAR CELL (2014)
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
Carolin Anders et al.
NATURE (2014)
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2014)
Dimeric CRISPR RNA-guided Fokl nucleases for highly specific genome editing
Shengdar Q. Tsai et al.
NATURE BIOTECHNOLOGY (2014)
CRISPR-Cas systems for editing, regulating and targeting genomes
Jeffry D. Sander et al.
NATURE BIOTECHNOLOGY (2014)
Fusion of catalytically inactive Cas9 to Fokl nuclease improves the specificity of genome modification
John P. Guilinger et al.
NATURE BIOTECHNOLOGY (2014)
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
Bin Shen et al.
NATURE METHODS (2014)
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
Ines Fonfara et al.
NUCLEIC ACIDS RESEARCH (2014)
Homology-directed repair of DNA nicks via pathways distinct from canonical double-strand break repair
Luther Davis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
Martin Jinek et al.
SCIENCE (2014)
Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells
Yilan Zhang et al.
SCIENTIFIC REPORTS (2014)
Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?
Mireille Betermier et al.
PLOS GENETICS (2014)
Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice
Angus Yiu-fai Lee et al.
FEBS OPEN BIO (2014)
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
F. Ann Ran et al.
CELL (2013)
Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis
Yan Zhang et al.
MOLECULAR CELL (2013)
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence
Timothy R. Sampson et al.
NATURE (2013)
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
Prashant Mali et al.
NATURE BIOTECHNOLOGY (2013)
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Seung Woo Cho et al.
NATURE BIOTECHNOLOGY (2013)
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2013)
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
Kevin M. Esvelt et al.
NATURE METHODS (2013)
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
Thomas J. Cradick et al.
NUCLEIC ACIDS RESEARCH (2013)
Mammalian Base Excision Repair: the Forgotten Archangel
Grigory L. Dianov et al.
NUCLEIC ACIDS RESEARCH (2013)
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
Zhonggang Hou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali et al.
SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
Giedrius Gasiunas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
Elitza Deltcheva et al.
NATURE (2011)
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
Michael R. Lieber
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)
CRISPR provides acquired resistance against viruses in prokaryotes
Rodolphe Barrangou et al.
SCIENCE (2007)
Share Paper
