Journal
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Volume 31, Issue 1, Pages 201-222Publisher
SPRINGER
DOI: 10.1007/s10334-017-0644-x
Keywords
MRI; Atherosclerosis; Quantitative imaging; Vessel wall imaging; Plaque imaging
Funding
- VENI Grant from the Dutch Technology Foundation STW [14348]
- NIH/NHLBI [R01 HL071021]
- American Heart Association Scientist Development Grant [16SDG27250090]
- Dutch Technology Foundation STW [HTSM 13928, CARISMA 11631]
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The past decade has witnessed the rapid development of new MRI technology for vessel wall imaging. Today, with advances in MRI hardware and pulse sequences, quantitative MRI of the vessel wall represents a real alternative to conventional qualitative imaging, which is hindered by significant intra- and inter-observer variability. Quantitative MRI can measure several important morphological and functional characteristics of the vessel wall. This review provides a detailed introduction to novel quantitative MRI methods for measuring vessel wall dimensions, plaque composition and permeability, endothelial shear stress and wall stiffness. Together, these methods show the versatility of non-invasive quantitative MRI for probing vascular disease at several stages. These quantitative MRI biomarkers can play an important role in the context of both treatment response monitoring and risk prediction. Given the rapid developments in scan acceleration techniques and novel image reconstruction, we foresee the possibility of integrating the acquisition of multiple quantitative vessel wall parameters within a single scan session.
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