Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 78, Issue 5, Pages 1683-1690Publisher
WILEY
DOI: 10.1002/mrm.26882
Keywords
diffusion tensor imaging (DTI); susceptibility tensor imaging (STI); magnetic susceptibility; magnetic susceptibility anisotropy; knee; collagen fibril; articular cartilage
Funding
- National Institutes of Health [NIMH R01MH096979, NIBIB 5P41EB015897, NIH 1S10OD010683]
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Purpose: To investigate the B-0 orientation-dependent magnetic susceptibility of collagen fibrils within the articular cartilage and to determine whether susceptibility tensor imaging (STI) can detect the 3D collagen network within cartilage. Methods: Multiecho gradient echo datasets (100-mu m isotropic resolution) were acquired from fixed porcine articular cartilage specimens at 9.4 T. The susceptibility tensor was calculated using phase images acquired at 12 or 15 different orientations relative to B-0. The susceptibility anisotropy of the collagen fibril was quantified and diffusion tensor imaging (DTI) was compared against STI. 3D tractography was performed to visualize and track the collagen fibrils with DTI and STI. Results: STI experiments showed the distinct and significant anisotropic magnetic susceptibility of collagen fibrils within the articular cartilage. STI can be used to measure and quantify susceptibility anisotropy maps. Furthermore, STI provides orientation information of the underlying collagen network via 3D tractography. Conclusion: The findings of this study demonstrate that STI can characterize the orientation variation of collagen fibrils where diffusion anisotropy fails. We believe that STI could serve as a sensitive and noninvasive marker to study the collagen fibrils microstructure. (C) 2017 International Society for Magnetic Resonance in Medicine.
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