Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 79, Issue 3, Pages 1708-1721Publisher
WILEY
DOI: 10.1002/mrm.26813
Keywords
CEST; paraCEST; qCEST; QUESP; QUEST; Bloch-McConnell; quantification
Funding
- Max Planck Society
- German Research Foundation (DFG) [ZA 814/2-1]
- European Union's Horizon Research and Innovation Programme [667510]
- Department of Health's NIHR Biomedical Research Centre's funding scheme
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PurposeChemical exchange saturation transfer (CEST) NMR or MRI experiments allow detection of low concentrated molecules with enhanced sensitivity via their proton exchange with the abundant water pool. Be it endogenous metabolites or exogenous contrast agents, an exact quantification of the actual exchange rate is required to design optimal pulse sequences and/or specific sensitive agents. MethodsRefined analytical expressions allow deeper insight and improvement of accuracy for common quantification techniques. The accuracy of standard quantification methodologies, such as quantification of exchange rate using varying saturation power or varying saturation time, is improved especially for the case of nonequilibrium initial conditions and weak labeling conditions, meaning the saturation amplitude is smaller than the exchange rate (B-1
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