Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 78, Issue 6, Pages 2322-2333Publisher
WILEY
DOI: 10.1002/mrm.26623
Keywords
Alzheimer's disease; white matter; diffusion-weighted imaging; fractional anisotropy; tensor distribution function
Funding
- ADNI (National Institutes of Health Grant) [U01 AG024904]
- DOD ADNI (Department of Defense award) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen Idec Inc.
- Bristol-Myers Squibb Company
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC
- Johnson & Johnson Pharmaceutical Research & Development LLC
- Medpace, Inc.
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Synarc Inc.
- Takeda Pharmaceutical Company
- Canadian Institutes of Health Research
- BD2K Initiative [U54 EB020403]
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PurposeIn diffusion MRI (dMRI), fractional anisotropy derived from the single-tensor model (FA(DTI)) is the most widely used metric to characterize white matter (WM) microarchitecture, despite known limitations in regions with crossing fibers. Due to time constraints when scanning patients in clinical settings, high angular resolution diffusion imaging acquisition protocols, often used to overcome these limitations, are still rare in clinical population studies. However, the tensor distribution function (TDF) may be used to model multiple underlying fibers by representing the diffusion profile as a probabilistic mixture of tensors. MethodsWe compared the ability of standard FA(DTI) and TDF-derived FA (FA(TDF)), calculated from a range of dMRI angular resolutions (41, 30, 15, and 7 gradient directions), to profile WM deficits in 251 individuals from the Alzheimer's Disease Neuroimaging Initiative and to detect associations with 1) Alzheimer's disease diagnosis, 2) Clinical Dementia Rating scores, and 3) average hippocampal volume. ResultsAcross angular resolutions and statistical tests, FA(TDF) showed larger effect sizes than FA(DTI), particularly in regions preferentially affected by Alzheimer's disease, and was less susceptible to crossing fiber anomalies. ConclusionThe TDF corrected form of FA may be a more sensitive and accurate alternative to the commonly used FA(DTI), even in clinical quality dMRI data. Magn Reson Med 78:2322-2333, 2017. (c) 2017 International Society for Magnetic Resonance in Medicine.
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