Super-resolution intracranial quiescent interval slice-selective magnetic resonance angiography

PurposeTo evaluate the combination of nonenhanced quiescent-interval slice-selective (QISS) magnetic resonance angiography (MRA) with super-resolution reconstruction for portraying the intracranial arteries. MethodsThe intracranial arteries of seven volunteers were imaged at 3T using QISS MRA acquired with a flow-compensated fast low-angle shot (FLASH) readout and thin overlapping slices. The impacts of super-resolution reconstruction and various acquisition parameters on the delineation of intracranial arteries were quantified using four metrics: arterial-to-background contrast-to-noise ratio (CNR), arterial-to-background contrast, arterial sharpness, and arterial full-width-at-half-maximum (FWHM). Three-dimensional time-of-flight (TOF) MRA was also acquired. ResultsFor similar voxel sizes, QISS MRA displayed the intracranial arteries with an arterial-to-background contrast that exceeded 3D TOF MRA by 59-84%, depending on the k-space sampling trajectory (P<0.001). Super-resolution reconstruction improved CNR, contrast, and sharpness, while reducing arterial FWHM (P<0.001). Cardiac triggering provided minimal benefits, while Cartesian sampling provided higher CNR than radial sampling for multishot QISS (P<0.05). Scan time for a complete intracranial MRA was <90 s using an ungated single-shot QISS acquisition. ConclusionThin, overlapping-slice QISS leveraging super-resolution reconstruction is a flexible approach for intracranial MRA that provides competitive image quality to standard-of-care 3D TOF, with the potential for reduced sensitivity to in-plane flow saturation and motion artifacts. Magn Reson Med 79:683-691, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.