Journal
MAGNETIC RESONANCE IMAGING
Volume 43, Issue -, Pages 144-150Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2017.07.025
Keywords
Ketamine; Resting-state; Local functional properties; Rhesus monkey
Funding
- Double First-rate Special Funds of Beihang University [ZG216S17C8]
- Special Funds for Beijing Base Construction & Talent Cultivation [Z171100002217066]
- International Science & Technology Cooperation Program of China [2014DFA30640]
- State Key Program of National Natural Science Foundation of China [31320103903, 31271037]
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Objective: Ketamine is a well-known anesthetic. 'Recreational' use of ketamine common induces psychosis-like symptoms and cognitive impairments. The acute and chronic effects of ketamine on relevant brain circuits have been studied, but the effects of single-dose ketamine administration on the local resting-state functional properties of the brain remain unknown. In this study, we aimed to assess the effects of single-dose ketamine administration on the brain local intrinsic properties. Methods: We used resting-state functional magnetic resonance imaging (rs-fMRI) to explore the ketamine-induced alterations of brain intrinsic properties. Seven adult rhesus monkeys were imaged with rs-fMRI to examine the fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) in the brain before and after ketamine injection. Paired comparisons were used to detect the significantly altered regions. Results: Results showed that the fALFF of the prefrontal cortex (p = 0.046), caudate nucleus (left side, p = 0.018; right side, p = 0.025), and putamen (p = 0.020) in post-injection stage significantly increased compared with those in pre-injection period. The ReHo of nucleus accumbens (p = 0.049), caudate nucleus (p = 0.037), and hippocampus (p = 0.025) increased after ketamine injection, but that of prefrontal cortex decreased (p < 0.05). Conclusions: These findings demonstrated that single-dose ketamine administration can change the regional intensity and synchronism of brain activity, thereby providing evidence of ketamine-induced abnormal resting state functional properties in primates. This evidence may help further elucidate the effects of ketamine on the cerebral resting status. (C) 2017 Published by Elsevier Inc.
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