Journal
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
Volume 6, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/jcdd6010002
Keywords
heart; zebrafish; regeneration; enhancer; transcription; gene regulation; development
Categories
Funding
- UW-Madison Stem Cell and Regenerative Medicine Center start-up fund [AAC8979]
- School of Medicine and Public Health start-up fund [AAC8355]
- Cell and Regenerative Biology start-up fund
- American Heart Association [AHA16SDG30020001]
- [AAC6429]
Ask authors/readers for more resources
The heart plays the vital role of propelling blood to the entire body, which is essential to life. While maintaining heart function is critical, adult mammalian hearts poorly regenerate damaged cardiac tissue upon injury and form scar tissue instead. Unlike adult mammals, adult zebrafish can regenerate injured hearts with no sign of scarring, making zebrafish an ideal model system with which to study the molecular mechanisms underlying heart regeneration. Investigation of heart regeneration in zebrafish together with mice has revealed multiple cardiac regeneration genes that are induced by injury to facilitate heart regeneration. Altered expression of these regeneration genes in adult mammals is one of the main causes of heart regeneration failure. Previous studies have focused on the roles of these regeneration genes, yet the regulatory mechanisms by which the expression of cardiac regeneration genes is precisely controlled are largely unknown. In this review, we will discuss the importance of differential gene expression for heart regeneration, the recent discovery of cardiac injury or regeneration enhancers, and their impact on heart regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available