Journal
MACROMOLECULAR BIOSCIENCE
Volume 17, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201600532
Keywords
acid-labile; degradation studies; drug delivery; in situ NMR kinetics; ketal; PEG
Funding
- Max Planck Graduate Center
- Johannes Gutenberg University Mainz (MPGC)
- Excellence Initiative in the context of the graduate school of excellence MAINZ (Materials Science in Mainz) [DFG/GSC 266]
Ask authors/readers for more resources
The authors introduce poly(ethylene glycol) (PEG) based macromonomers containing acid-labile ketal moieties as well as terminal methacrylate units that are amenable to radical polymerization. The synthesis of PEGs of different molecular weights (ranging from 2000 to 13 000 g mol(-1) with polydispersities <1.15) with a central ketal unit (PEG-ketal-diol) and their conversion to PEG-ketal-dimethacrylates (PEG-ketal-DMA) is introduced. Degradation rates of both PEG-ketal-diols and PEG-ketal-DMA are investigated by in situ H-1 NMR kinetic studies in deuterated phosphate buffer. Hydrogels containing 0, 5, or 10 wt% of PEG-ketal-DMA and 100, 95, or 90 wt% of PEG-DMA, respectively, are synthesized and disintegration of the gels is investigated in buffer at different pH values. Visible disintegration of the gels appears at pH 5 for hydrogels containing PEG-ketal-DMA, whereas no visible degradation is observed at all at neutral pH or for PEG hydrogels without PEG-ketal-DMA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available