Journal
MACROMOLECULAR BIOSCIENCE
Volume 17, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201700250
Keywords
cancer; imprinted polymer; molecular recognition; pseudouridine; tailor-made monomer
Funding
- ANR
- University of Kent
- [ANR-10-TECS-0004]
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Pseudouridine () is an important urinary cancer biomarker, especially in human colorectal cancer (CRC). Disclosed herein is the first molecularly imprinted polymer (-MIP) material obtained from tailor-engineered functional monomers. The resulting MIP imprint exhibits a remarkable imprinting factor greater than 70. It is successfully used for the selective recognition of in spiked human urine. This selective functionalized material opens the route to the development of inexpensive disposable chemosensors for noninvasive CRC diagnosis and prognosis.
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