Journal
MACROMOLECULAR BIOSCIENCE
Volume 17, Issue 11, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201700177
Keywords
amino acids; chemoenzymatic polymerization; polypeptides; proteases; structural proteins
Funding
- RIKEN Biomass Engineering Program, JST ERATO [JPMJER1602]
- Impulsing Paradigm Change through Disruptive Technologies Program (ImPACT) of the Japan Science and Technology Corporation (JST)
- Cross-Ministerial Strategic Innovation Promotion Program (SIP) of the National Agriculture and Food Research Organization
- New Energy and Industrial Technology Development Organization (NEDO)
- Sumitomo Foundation
- Japan Society for the Promotion of Science (JSPS) [17K18361]
- Grants-in-Aid for Scientific Research [17K18361] Funding Source: KAKEN
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Polypeptides inspired by the natural functional and structural proteins present in living systems are promising materials for various fields in terms of their versatile functionality and physical properties. Designing and synthesizing mimetic sequences of specific peptide motifs in proteins are important for exploring the functionality of natural proteins. Chemoenzymatic polymerization, which utilizes aminolysis (i.e., the reverse reaction of hydrolysis catalyzed by proteases), is a useful technique for synthesizing artificial polypeptide materials and has several advantages, including facile synthesis protocols, environmental friendliness, scalability, and atom economy. In this review, recent progress in chemoenzymatic polypeptide synthesis for the production of functional and structural materials for various applications is summarized in conjunction with the current status of technical challenges in the field.
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