Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 35, Pages 5135-5138Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01598a
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Funding
- U.S. National Institutes of Health [GM127295]
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We describe the synthesis and RNA acylation activity of a series of minimalist azidoalkanoyl imidazole reagents, with the aim of functionalizing RNA at 2-hydroxyl groups at stoichiometric to superstoichiometric levels. We find marked effects of small structural changes on their ability to acylate and be reductively removed, and identify reagents and methods that enable efficient RNA functionalization and control.
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