Journal
DALTON TRANSACTIONS
Volume 48, Issue 16, Pages 5308-5314Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9dt00719a
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Funding
- National Natural Science Foundation of China [21871203, 21874064, 21671143]
- Natural Science Foundation of Guangdong [2018A030313456]
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Defects within the nanoscale UiO-66 metal-organic framework (MOF) are created to lock a hybrid phosphonoacetate ligand through Zr-O-P linkages, leaving the carboxyl group free to anchor cisplatin prodrug cis, cis, trans-[Pt(NH3)(2)Cl-2(OH)(2)]. A drug loading of 256.5 mg g(-1) (25.7 wt% based on cisplatin) was achieved with a Zr-6:Pt:P ratio of 1.5:1:1, which surpasses defect-free UiO-66 and several other MOF carriers. This framework exhibited a burst release of its payload in PBS solution in the first 2 h, releasing 71% of the drug, including a 50% payload release in less than 1 h. This work demonstrates that MOF defects can be intentionally engineered to achieve a high drug loading, and serves as an alternative to drug encapsulation using the pore void and through the association of the functionalized ligand.
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