4.6 Article

In situ aqueous synthesis of genetically engineered polypeptide-capped Ag2S quantum dots for second near-infrared fluorescence/photoacoustic imaging and photothermal therapy

Journal

JOURNAL OF MATERIALS CHEMISTRY B
Volume 7, Issue 15, Pages 2484-2492

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb03043j

Keywords

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Funding

  1. National Key Research and Development Program of China [2017YFA0700501]
  2. National Natural Science Foundation of China [81871414]
  3. Applied Basic Research Program of Wuhan City [2016060101010044]
  4. China Postdoctoral Science Foundation [2017M612462]
  5. Fundamental Research Funds for the Central Universities [HUST: 2017KFXKJC002, 2018KFYXKJC048]

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Ag2S quantum dots have received extensive attention as theranostic agents for second near-infrared (NIR-II) fluorescence and photoacoustic dual-mode imaging, and photothermal therapy. However, it is still greatly challenging to synthesize Ag2S quantum dots using aqueous synthesis. In this study, genetically engineered polypeptide-capped Ag2S quantum dots were successfully synthesized. Three cysteines were integrated to the C-terminal and N-terminal of RGDPC(10)A to enhance the stability and brightness of the synthesized Ag2S quantum dots. The RGDPC(10)A-capped Ag2S quantum dots exhibited excellent stability, outstanding resistance to photobleaching, and a superior quantum yield of up to 3.78% in the NIR-II biological window. The in vitro and in vivo results showed that the RGDPC(10)A-capped Ag2S quantum dots possessed typical NIR-II fluorescence, photoacoustic imaging, and photothermal therapeutic effectiveness against tumors. Moreover, the results of toxicity assays suggested that the RGDPC(10)A-capped Ag2S quantum dots have negligible long-term toxicity. These findings open up the possibility for synthesizing theranostic agents by using this aqueous method.

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