4.5 Article

Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Comparison of biosensor platforms in the evaluation of high affinity antibody-antigen binding kinetics

Danlin Yang et al.

ANALYTICAL BIOCHEMISTRY (2016)

Article Pharmacology & Pharmacy

PK/PD analysis of a novel pH-dependent antigen-binding antibody using a dynamic antibody-antigen binding model

Kenta Haraya et al.

DRUG METABOLISM AND PHARMACOKINETICS (2016)

Article Medicine, Research & Experimental

De novo isolation of antibodies with pH-dependent binding properties

Pauline Bonvin et al.

Article Biochemistry & Molecular Biology

pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

M. Jack Borrok et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

pH-dependent antigen-binding antibodies as a novel therapeutic modality

T. Igawa et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2014)

Article Biotechnology & Applied Microbiology

Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery

E-Chiang Lee et al.

NATURE BIOTECHNOLOGY (2014)

Article Medicine, Research & Experimental

The effect of pH dependence of antibody-antigen interactions on subcellular trafficking dynamics

Siva Charan Devanaboyina et al.

Article Multidisciplinary Sciences

Engineered Monoclonal Antibody with Novel Antigen-Sweeping Activity In Vivo

Tomoyuki Igawa et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9

Javier Chaparro-Riggers et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Pharmacology & Pharmacy

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Dhaval K. Shah et al.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2012)

Article Biochemistry & Molecular Biology

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma

Jacek R. Wisniewski et al.

MOLECULAR SYSTEMS BIOLOGY (2012)

Review Oncology

Antibody therapy of cancer

Andrew M. Scott et al.

NATURE REVIEWS CANCER (2012)

Article Biotechnology & Applied Microbiology

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

Tomoyuki Igawa et al.

NATURE BIOTECHNOLOGY (2010)

Review Immunology

Therapeutic antibodies for autoimmunity and inflammation

Andrew C. Chan et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Review Oncology

Paul Ehrlich's magic bullet concept: 100 years of progress

Klaus Strebhardt et al.

NATURE REVIEWS CANCER (2008)

Article Pharmacology & Pharmacy

Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice

Amit Garg et al.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2007)

Article Pharmacology & Pharmacy

Eculizumab: A novel therapy for paroxysmal nocturnal hemoglobinuria

Karolina M. Zareba

DRUGS OF TODAY (2007)

Article Multidisciplinary Sciences

Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy

Prashant Prabhat et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Immunology

FcRn: the neonatal Fc receptor comes of age

Derry C. Roopenian et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Article Biochemistry & Molecular Biology

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn)

William F. Dall'Acqua et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Pharmacology & Pharmacy

Elimination mechanisms of therapeutic monoclonal antibodies

MA Tabrizi et al.

DRUG DISCOVERY TODAY (2006)

Article Multidisciplinary Sciences

Exocytosis of IgG as mediated by the receptor, FcRn: An analysis at the single-molecule level

RJ Ober et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)