Journal
LUNG CANCER
Volume 103, Issue -, Pages 66-74Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2016.11.020
Keywords
Lung cancer; Treatment; Surgery; Radiation; Chemotherapy; Targeted therapy survival
Categories
Funding
- National Cancer Institute [HHSN261201000024C, HHSN261201000025C, HHSN261201000-032C, HHSN261201000027C, HHSN261201000026C, HHSN261-201000140C, HHSN261201000037C, HHSN261201000033C, HH-SN261201000034C, HHSN261201000035C, HHSN261201000-029C, HHSN261201000031C, HHSN261201000028C, HHSN261201000030C]
Ask authors/readers for more resources
Introduction: Lung cancer remains a common and deadly cancer in the United States. This study evaluated factors associated with stage-specific cancer therapy and survival focusing on temporal trends and sociodemographic disparities. Methods: A random sample (n=3,318) of non-small cell lung cancer (NSCLC) patients diagnosed in 1996, 2005 and 2010, and reported to the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) program was analyzed. Logistic regression was utilized to identify factors associated with receipt of surgery among stage patients and chemotherapy among stage IIIB/IV patients. Cox proportional hazard regression was utilized to assess factors associated with all-cause mortality, stratified by stage. Results: Surgery among stage I/II patients decreased non-significantly overtime (1996: 78.8%; 2010: 68.5%; p = 0.18), whereas receipt of chemotherapy among stage IIIB/IV patients increased significantly overtime (1996: 36.1%; 2010: 51.2%; p < 0.01). Receipt of surgery (70-79 and >= 80 vs. <70: Odds Ratio(OR):0.31; 95% Confidence Interval (CI): 0.16-0.63 and OR:0.04; 95% CI: 0.02-0.10, respectively) and chemotherapy (>= 80 vs. <70: OR: 0.26; 95% CI:0.15-0.45) was less likely among older patients. Median survival improved non-significantly among stage patients from 51 to 64 months (p = 0.75) and significantly among patients from 4 to 5 months (p < 0.01). Conclusion: Treatment disparities were observed in both stage groups, notably among older patients. Among stage patients, survival did not change significantly possibly due to stable surgery utilization. Among stage IIIB/IV patients, although the use of chemotherapy increased and survival improved, the one-month increase in median survival highlights the need for addition research. Published by Elsevier Ireland Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available