Journal
LUNG CANCER
Volume 103, Issue -, Pages 24-26Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2016.11.012
Keywords
Lung cancer; Adenocarcinoma; Squamous cell carcinoma; EGFR; Mutation
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The occurrence of secondary EGFR mutation T790 M in exon 20 and histologic transformation are common mechanisms underlying resistance to EGFR first- or second-generation tyrosine kinase inhibitors (TKI). We describe here on a hitherto unreported mechanism of EGFR TKI resistance synchronously combining squamous-cell carcinoma change and occurrence of the EGFR exon 20 S768I secondary mutation in a 43 year-old woman with stage IV adenocarcinoma harbouring EGFR exon 21 L858R mutation. After 8 months of response to gefitinib, the patient experienced EGFR TKI resistance and died of leptomeningeal neoplastic dissemination. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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