Journal
LIVESTOCK SCIENCE
Volume 203, Issue -, Pages 106-109Publisher
ELSEVIER
DOI: 10.1016/j.livsci.2017.07.012
Keywords
Inhibin alpha gene; Litter size; Goats
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This study was conducted to identify SNPs in inhibin alpha (INHA) gene and investigate their association with litter size in two Nigerian goat breeds {West African Dwarf (WAD, n = 226), Red Sokoto (RS, n = 70)} and Kalahari Red (KR, n = 70). Sequence analyses revealed four SNPs {g. -65C > G/rs643347356 (5'UTR), g.2518G > A (a novel variant in exon 2), g.3041A > G/rs641311609 (exon 3) and g.3234C > T/rs670889338 (3'UTR)1. Homozygous wild type CC at g. -65C > G and GG at g.2518G > A loci were predominant genotypes in Kalahari Red goats. CC was the predominant genotype in all the three breeds at g.3234C > T locus and the frequency of allele C was 0.88, 0.98 and 0.98 in WAD, RS and KR populations respectively. Allele diversity index was low (He < 0.3) in the three breeds at g. -65C > G, g.2518G > A and g.3234C > T loci. WAD and KR goats had moderate genetic diversity (0.25 <= PIC <= 0.5) at g.3041A > G locus. Pair-wise comparison revealed that does having CT genotype at g.3234 C > T locus had significantly (P = 0.01) larger litter size compared with CC in WAD goats, while SNP genotype at other loci were not significantly associated with litter size.
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