Journal
LIVER INTERNATIONAL
Volume 37, Issue 8, Pages 1202-1208Publisher
WILEY
DOI: 10.1111/liv.13363
Keywords
apolipoprotein B; incidence; non-alcoholic fatty liver disease; prospective studies
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Funding
- Zhejiang Provincial Natural Science Foundation of China [LR15H030001]
- National Natural Science Foundation of China [81470838, 81230012]
- International Science and Technology Cooperation Projects of Zhejiang Province [2013C24010]
- Science Foundation of Health Bureau of Zhejiang Province [2012RCA026]
- Scientific Research Fund of Zhejiang Provincial Education Department [Y201430623]
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Background & Aims: Cross-sectional studies have shown that apolipoprotein B (apoB) is positively associated with the prevalence of non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the prospective relationship between the serum apoB levels and the development of NAFLD in a Chinese population. Methods: A cohort of 7077 initially NAFLD-free participants was enrolled in this prospectively study. The incidence of NAFLD was calculated among participants with different baseline serum apoB quintiles. Cox proportional hazards regression analyses were conducted to calculate the risks for incident NAFLD. Results: During 41 555 person-year follow-ups, 1139 incident NAFLD cases were identified. The baseline apoB levels were linear and positively correlated with NAFLD incidence. The incidence was 16.99, 22.63, 24.73, 37.51 and 42.77 per 1000 person-year follow-up for participants with baseline apoB levels in quintiles 1-5, respectively. Compared with participants with baseline apoB levels in quintile 1, the hazard ratios (95% confidence interval) for incident NAFLD were 1.353 (1.100-1.663), 1.482 (1.207-1.820), 2.232 (1.832-2.720) and 2.543 (2.082-3.106) for participants with baseline apoB levels in quintile 2-5, respectively. The hazard ratios were attenuated but remained statistically significant after adjusting for age, gender, body mass index and variables associated with metabolic syndrome. Conclusion: Elevated serum apoB levels independently predict an increased risk for incident NAFLD.
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