Journal
MATERIALS HORIZONS
Volume 6, Issue 4, Pages 810-816Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8mh01286e
Keywords
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Funding
- National High Technology Research and Development Program [2016YFA-0200303]
- National Natural Science Foundation of China [31771095, 51573188, 31522023]
- Strategic Priority Research Program'' of the Chinese Academy of Sciences [XDA09030301-3]
- Beijing Municipal Science & Technology Commission [Z161100002616015]
- Beijing Natural Science Foundation [L172046]
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A hybrid clusterbomb' as a multifunctional nanoplatform (MPSDP-ZnO/Ag) was developed for the combined immunotherapy of intracranial tumors. MPSDP-ZnO/Ag possessed high antigen loading and well-defined hybrid nanostructures, and could trigger the cluster to bomb' in response to antigen-presenting cells for simultaneous antigen and adjuvant release. The in vitro and in vivo results confirmed significant antigen accumulation and enhanced cellular and humoral immunity. More importantly, our nanovaccines obviously prolonged the survival time of tumor-bearing mice without systemic toxicity.
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