Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 17, Pages 4225-4229Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00572b
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Funding
- Japan Society for the Promotion of Science [17K05794]
- Grants-in-Aid for Scientific Research [17K05794] Funding Source: KAKEN
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We describe herein the synthetic method to benzoxazole derivatives via the copper-catalyzed hydroamination of alkynones with 2-aminophenols. The method produced a wide variety of functionalized benzoxazole derivatives in good yields. Preliminary mechanistic experiments revealed that the reaction would proceed through the copper-catalyzed hydroamination of alkynones and the sequential intramolecular cyclization of beta-iminoketones/elimination of acetophenone promoted by the copper catalyst.
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