4.6 Article

Synthesis of benzoxazoles via the copper-catalyzed hydroamination of alkynones with 2-aminophenols

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 17, Pages 4225-4229

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00572b

Keywords

-

Funding

  1. Japan Society for the Promotion of Science [17K05794]
  2. Grants-in-Aid for Scientific Research [17K05794] Funding Source: KAKEN

Ask authors/readers for more resources

We describe herein the synthetic method to benzoxazole derivatives via the copper-catalyzed hydroamination of alkynones with 2-aminophenols. The method produced a wide variety of functionalized benzoxazole derivatives in good yields. Preliminary mechanistic experiments revealed that the reaction would proceed through the copper-catalyzed hydroamination of alkynones and the sequential intramolecular cyclization of beta-iminoketones/elimination of acetophenone promoted by the copper catalyst.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available