Journal
ACTA DERMATO-VENEREOLOGICA
Volume 99, Issue 6, Pages 557-563Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-3136
Keywords
HPV; anal canal; oral mucosa; anogenital warts; epidemiology.
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Funding
- Sanofi Pasteur MSD, Portugal
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Human papillomavirus (HPV) infection is highly prevalent in the sexually active population. This study estimates the prevalence of HPV DNA in anal and oral samples from a cohort of men and women with incident anogenital warts. Anal and/ or oral samples from 541 patients with anogenital warts were tested for 35 HPV genotypes using a PCR assay. The overall prevalence of anal HPV and oral HPV DNA was 59.9% (n = 305/ 509; 95% confidence interval (CI) 55.664.1%) and 14.5% (n = 78/ 538; 95% CI 11.8-17.7%), respectively. Among patients with perianal warts, the anal HPV DNA prevalence was 92.3% (95% CI 87.095.5%). Anal HPV DNA prevalence in patients with genital warts but no perianal warts was 55.7% (95% CI 50.6-60.7%). Both anal and oral HPV infections were more common in men who have sex with men than in heterosexual men (90.4% versus 38.5% and 20.8% versus 11.8%, respectively). Anal high risk-HPV infection was more common in women (58.8%) and in men who have sex with men (67.7%). We found that anogenital warts represent a clinical marker for both anal and oral HPV infections, including anal high risk-HPV infections, particularly among women and men who have sex with men.
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