Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2019.00023
Keywords
CDKs; cyclins; non-cell cycle functions; innate immune system; adaptive immune system; immunosurveillance
Categories
Funding
- Thailand Research Fund [RSA5880038]
- National Science and Technology Development Agency Thailand [P-15-50208]
- Siriraj Research Fund
- Foundation for Cancer Care of Siriraj Hospital
- Advanced Research on Pharmacology Fund of Siriraj Hospital
- Siriraj Foundation [D003421]
- Siriraj Graduate Thesis Scholarship
- Chalermphrakiat Grant, Faculty of Medicine Siriraj Hospital, Mahidol University
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Core cell cycle regulators, including cyclin-dependent kinases (CDKs), cyclins, and cyclin-dependent kinase inhibitors (CKIs), are known for their well-characterized roles in cell division. Several recent studies have shed light on the roles of these proteins in immune modulation. The development and activation of cells in the immune system take place not only during embryonic development but throughout the life of a multicellular organism. Cell cycle regulators are involved in the development of immune cells, partly as the machinery controlling the expansion and differentiation of the populations of immune cells. In addition, these proteins serve non-cell cycle functions. In this review, we summarize the emerging roles of cell cycle regulators in modulating functions of the immune system and discuss how they may be exploited as therapeutic targets.
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