Journal
LEUKEMIA RESEARCH
Volume 57, Issue -, Pages 72-77Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2017.01.028
Keywords
miR-137; c-kit; Acute myeloid leukemiaa
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Funding
- National Natural Science Foundation of China [31571198]
- Outstanding Scientific Fund of Shengjing Hospital [ME57]
- Outstanding PhD projects of Shengjing Hospital [MD66]
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The oncogene c-kit plays a vital role in the pathogenesis of acute myeloid leukemia (AML). However, the mechanism of microRNAs targeting c-kit in AML has not been determined in detail. Moreover, the role miR-137 in tumor cell proliferation remains controversial. The aim of this work was to verify whether miR-137 targets c-kit and to research the biological effects of restoring miR-137 expression in leukemia cells. We found that miR-137 binds specifically to the 3'-UTR of c-kit and suppresses the expression and activities of c-kit. There is a negative correlation between miR-137 and c-kit expression in both patients and cell lines determined by screening large clinical samples. We found that miR-137 can inhibit proliferation, promote apoptosis, and induce differentiation of c-kit+ AML cells. We determined that miR-137 can participate in the leukemogenesis by regulating c-kit, which could be used as a therapeutic target for acute myeloid leukemia. Copyright (C) 2017 Elsevier Ltd. All rights reserved.
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