Journal
GELS
Volume 5, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/gels5010005
Keywords
peptides; D-amino acids; chirality; hydrogels; drugs; release; self-assembly; 5-fluorouracil
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Funding
- Italian Ministry of University and Research (MIUR) through the Scientific Independence of young Researchers (SIR) program [RBSI14PBC6, RBSI14A7PL]
- Ramon Areces Foundation
- Beneficentia Stiftung Fundation
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In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide assemblies was probed by all-atom molecular dynamics simulations.
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