Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2019.00033
Keywords
hippo; yap; liver; hepatocellular carcinoma; HCC; cholangiocarcinoma; fibrosis; steatohepatitis
Categories
Funding
- Wilhelm Sander-Stiftung, Germany [2017.115.1]
Ask authors/readers for more resources
The first description of Hippo signaling in mammals a little more than 10 years ago showed a striking phenotype in the liver, linking the role of this signaling pathway to organ size control and carcinogenesis. Even though Hippo signaling has been extensively studied in the liver and other organs over the recent years, many open questions remain in our understanding of its role in hepatic physiology and disease. The functions of Hippo signaling extend well beyond cancer and organ size determination: components of upstream Hippo signaling and the downstream effectors YAP and TAZ are involved in a multitude of cell and non-cell autonomous functions including cell proliferation, survival, development, differentiation, metabolism, and cross-talk with the immune system. Moreover, regulation and biological functions of Hippo signaling are often organ or even cell-type specific-making its role even more complex. Here, we give a concise overview of the role of Hippo signaling in the liver with a focus on celltype specific functions. We outline open questions and future research directions that will help to improve our understanding of this important pathway in liver disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available