Journal
ACS APPLIED BIO MATERIALS
Volume 2, Issue 5, Pages 2280-2293Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00239
Keywords
biowaste; seashells; ascorbic acid; microwave-assisted synthesis; mesoporous hydroxyapatite; implant applications
Funding
- Korean Research Fellowship program - Ministry of Science and ICT through the National Research Foundation of Korea (KRF) [2018H1D3A1A01037054]
- Ministry of Education and Science of the Russian Federation [211]
- National Research Foundation of Korea [2018H1D3A1A01037054] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Post-surgery implant infection is one of the most challenging issues in orthopedics and it is mainly caused by infective micro-organisms. A potential approach to overcome this issue is developing biomaterials with efficient antibacterial activity. The main intention of this present research is devoted to ascorbic acid-assisted microwave synthesis of mesoporous (silver) Ag-doped hydroxyapatite (HAp) nanorods using biowaste seashells with antibacterial properties. XRD, FTIR, and Raman spectroscopy results revealed that the synthesized nanoparticles are hexagonal crystalline HAp. Further, the silver-doped HAp was also successfully produced without affecting the HAp crystalline phase by forming electrostatic interaction with PO43- ions during the synthesis. The morphological features confirm that the pure HAp is elongated mesoporous nanorods with 20 nm width and 300-500 nm length. However, silver doped HAp nanoparticles such as AgHA-1, AgHA-2, and AgHA-3 are found to be similar mesoporous rods but with different aspect ratios in sizes of 15, 10-15, and 5-10 nm width and 80-100, 10-15, and 20-30 nm length. The BET specific surface areas were obtained as 29 +/- 3, 84 +/- 2, 87 +/- 2, and 128 +/- 3 m(2) g(-1), and pore diameters were 4.68, 4.18, 9.30, and 3.77 nm, respectively, for pure HA, AgHA-1, AgHA-2, and AgHA-3. Therefore, HAp nanoparticles with different dimensions and mesoporous structures could be rapidly prepared using a microwave-assisted method and ascorbic acid as a supporting material. In addition, the synthesized HAp nanoparticles are analyzed for its antibacterial and cytotoxicity studies. The antibacterial and cytotoxicity study clearly reveals that the Ag-doped HAp nanorods are efficiently antibacterial and nontoxic in nature. Hence, it is clear that the ascorbic acidenabled microwave-assisted method will be one of the best methods for the rapid production of HAp nanoparticles with different dimensions and mesoporous structures for its application as an implant material.Y
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