Journal
LASER PHYSICS LETTERS
Volume 14, Issue 3, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1612-202X/aa58c0
Keywords
optical coherence tomography; OCT signal slope; correlation coefficient; diabetic patients; blood glucose concentration
Categories
Funding
- National Natural Science Foundation of China [60778047, 61335011, 61275187, 81071790]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20114407110001, 200805740003]
- Science and Technology Innovation Project of the Education Department of Guangdong Province of China
- Natural Science Foundation of Guangdong Province of China [06025080, 9251063101000009]
- Technique invention program of Guangdong Province [2013KJCX0052]
- Science and Technology Project of Guangdong Province [2012A080203008]
- Key Laboratory of Optoelectronic Science and Technology for Medicine (Fujian Normal University), Ministry of Education, China [JYG1202]
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Optical coherence tomography (OCT) has been used to noninvasively monitor the blood glucose concentration (BGC) in healthy subjects with good accuracy and acceptable specificity. Based on this, the paper further considered the possibility of OCT in noninvasive monitoring BGC in diabetic patients. The OCT signal slope (OCTSS) changed with variation of BGC. The correlation coefficient R between BGC and OCTSS in diabetic patients was 0.91; while the correlation coefficient R in healthy volunteers was 0.78. Thus, a better linear dependence of OCTSS on BGC in diabetic patients was presented in the experiment. The results showed that the capability and accuracy of OCT in noninvasive monitoring BGC of diabetic patients, and the noninvasive monitoring BGC in diabetic patients may be better than the monitoring in the healthy subjects.
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