Journal
VETERINARY RESEARCH
Volume 50, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13567-019-0654-y
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Funding
- National Key Research and Development Program of China [2018YFD0500100]
- National Natural Science Foundation of China [31530074, 31872453]
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The fusogenically activated F and HN proteins of virulent NDV induce complete autophagic flux in DF-1 and A549 cells. However, the effect of both glycoproteins on mitochondria remains elusive. Here, we found that F and HN cooperation increases mitochondrial biogenesis but does not cause the mitochondria damage. We observed that both glycoproteins change the morphological characteristics and spatial distribution of intracellular mitochondria. F and HN cooperate cooperatively to induce ER stress and UPRmt. Our preliminary data suggested that F and HN cooperatively disturb mitochondrial fusion-fission homeostasis to enhance mitochondrial biogenesis, and eventually meet the energy demand of syncytium formation.
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